Frequency of the common promoter polymorphismMMP2 −1306 C>Tin a population from central Bulgaria
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چکیده
منابع مشابه
Frequency of the common promoter polymorphism MMP2 −1306 C>T in a population from central Bulgaria
Matrix metalloproteinases (MMPs) are a family of highly homologous extracellular Zn2+-dependent endopeptidases, also known as matrixins. MMP-2 (gelatinase A) and MMP-9 (gelatinase B) are considered to play a key role in a variety of physiological processes as well as in the development and progression of a vast majority of pathological conditions. Most of the genes encoding MMPs, including MMP-...
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Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with suscep...
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ژورنال
عنوان ژورنال: Biotechnology & Biotechnological Equipment
سال: 2015
ISSN: 1310-2818,1314-3530
DOI: 10.1080/13102818.2014.995411